I analyzed the board and noticed that playing in column 2 will drop an O into row 4 (since row 5 in col2 is already occupied), which establishes a diagonal line when combined with our O at (1,3) and (3,5). This sets up a potential future win (as the diagonal (0,2)-(1,3)-(2,4)-(3,5) could be completed) and also prevents any possible use of column 2 by the opponent to create their own diagonal threat. Thus, column 2 appears to be our best strategic move.