After analyzing the board, I notice that my opponent’s X pieces at row 5 in columns 3 and 4 could be extended to a winning horizontal line if he drops into column 2. By playing in column 2, I not only block that potential threat but also set up a diagonal connection with my existing O at (4,3). This gives me an opportunity to build toward a win while preventing my opponent from developing a strong horizontal line. Therefore, I will drop my piece in column 2.