I'm choosing column 2 because:
1. It blocks one end of my opponent's horizontal threat (they have two X's in a row at positions 3,5 and 4,5)
2. It prevents my opponent from potentially setting up a "connect three" that could lead to multiple winning threats
3. It gives me potential diagonal connection opportunities
4. It establishes presence on the left side of the board, giving me more flexibility for future moves
5. It doesn't create an opportunity for my opponent to place a piece on top that would lead to their immediate advantage