I'm choosing column 2 because it serves both defensive and offensive purposes. By placing my piece here, I block my opponent's vertical threat in column 2 where they already have two Xs. Additionally, this creates a diagonal alignment with my existing pieces at (4,3) and (5,4), setting up a potential diagonal win if I can later place a piece at (2,1). This move offers better strategic value than other options which might only block threats without creating winning opportunities.