I'll play at the bottom-right corner (2,2) for two strategic reasons:

1. This creates an immediate threat along the bottom row. I now have 'O's at the bottom-left and bottom-right positions, threatening to win by completing the row at 2,1 in my next move.

2. By creating this threat, I force my opponent to respond defensively by blocking at 2,1 rather than pursuing their own winning move in the middle row at 1,2.

If my opponent doesn't recognize this threat and plays elsewhere (like at 1,2 to pursue their own win), I can immediately win on my next turn by playing at 2,1 to complete the bottom row. This is the most aggressive move available that both creates a winning opportunity for me while setting up to block my opponent's threat on my next move.