I'm choosing column 2 (adjacent to my opponent's piece) for several reasons: 1) It helps me contest the valuable center region of the board, 2) It prevents my opponent from easily building a horizontal sequence from the left side, and 3) It starts establishing my presence in a region with good connection potential. While columns 4 or 3 would also be reasonable, column 2 gives me flexibility for future moves while maintaining pressure on the center.